|
New Data on all Patients in Study
Image-Guided Coils Reduce Death and Dependency for Brain Aneurysm Patients in Lancet Study
New data show that image-guided therapy for ruptured brain aneurysms-highly dangerous and often lethal-dramatically reduces dependency or death for many patients, according to a study in the peer-reviewed medical journal, The Lancet.1 The study reports on one-year and seven-year survival data for all 2,143 patients in the International Subarachnoid Aneurysm Trial that began in 1997.
The new data show fundamentally the same results as the interim report: Use of minimally invasive coils-guided by medical imaging-leads to a "significant reduction in the relative risk of death or dependency of 23.9 percent." That means that, one year after surgery, an equivalent of 74 more patients out of1,000 treated were alive or avoided dependency because they received the image-guided procedure.
- The report found that 30.9 percent of patients who received neurosurgery were dependent or dead after one year, versus 23.5 percent for those who received the image-guided coil procedure-a relative risk reduction of 23.9 percent. The survival advantage was maintained for at least 7 years (which is the period of time for which robust follow-up evidence is available) and was considered to be statistically significant. The risk of epilepsy was substantially lower in patients who received the coil therapy, but the risk of late rebleeding was higher, according to the study.
- How the procedure works: X-ray imaging is used to guide the procedure. Physicians watch video monitors that show the coil moving through the patient's veins, to the site of the hemorrhage. The coil is then released, closing the rupture. The alternate treatment involves performing a craniotomy in which surgeons remove a section of the patient's skull to place a surgical clip near the aneurysm.
| 1 |
"International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion,"
Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P
The Lancet - Vol. 366, Issue 9488, 3 September 2005, Pages 809-817 |
| 2 |
"International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial"
Molyneux A, The Lancet - Vol. 360, Issue 9342, 26 October 2002, Pages 1267-1274 |
|
