Publications & Research

Postop Radiation Slows PSA Rise in High-Risk Prostate Cancer

Men with high-risk prostate cancer had a significantly lower risk of biochemical relapse when treated with adjuvant radiation therapy after radical prostatectomy, results of a large randomized trial showed.

After a median follow-up of almost 11 years, men who received radiotherapy after removal of the prostate had a biochemical progression rate of 39.4% compared with 61.8% in men randomized to a wait-and-see policy after surgery.

The reduced risk of biochemical progression did not translate into a survival benefit, as the two treatment groups did not differ with respect to progression-free survival (PFS), distant metastasis-free survival, or overall survival, as reported online in The Lancet.

The results suggested older age might have had a detrimental effect on radiotherapy’s ability to improve clinical PFS.

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