Publications & Research

DWI-MRI helps reduce false-positive breast MRI scans

Researchers from the University of Washington School of Medicine and Seattle Cancer Care Alliance also found that DWI’s ability to differentiate between high-risk lesions and other nonmalignant tumor subtypes could enhance patient care and treatment management.

DWI measures ADC values, which relate to the movement of water mol­ecules in vivo and indirectly reflect tissue microstructural characteristics. Hence, as lead study author Dr. Sana Parsian and colleagues noted, DWI has been used primarily in neurological applications (Radiology, October 2, 2012).

However, more recently, DWI has been used with increasing frequency for breast imaging because it can help distinguish between benign and malignant breast lesions. DWI has also shown that low ADCs for breast carcinomas can indicate normal tissue or benign lesions.

In this study, researchers retrospectively reviewed an MRI da­tabase to identify consecutive suspicious breast lesions detect­ed by MRI from October 2005 to December 2008 that subsequently were sampled with a core needle or surgical biopsy.

A total of 175 nonmalignant lesions from 162 examinations among 161 women (median age, 48 years; range, 27-77) were included in the analysis. Lesions were assigned a BI-RADS assessment of 4 for suspicion of malignancy or 5 for a great suspicion of malignancy.
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